Multipeptide vaccination in cancer patients

摘要: Since the identification of tumor associated antigens (TAA) in different histotypes, many vaccination strategies have been investigated, including peptide-based vaccines. Results from first decade clinical experimentation, though demonstrating feasibility and good toxicity profile this approach, provided evidence activity only a minority patients, despite inducing immunization up to 50% them. In review, we discuss approaches recently developed order induce stronger peptide-induced immune-mediated growth control, possibly translating into improved response rates, with specific focus on multipeptide-based anti-cancer This strategy offers advantages, such as possibility bypassing heterogeneity selection antigen (Ag)-negative clones escaping peptide-specific immune responses, or combining HLA class I- II-restricted epitopes, thus eliciting both CD4- CD8-mediated recog...