Omics of Hereditary Breast Cancer

摘要: Breast cancer is the leading cause of cancer-related deaths among women worldwide. Although advances in our understanding this disease have been made last decade, available treatments remain inadequate, particularly for more intractable forms breast cancer. Hereditary or familial poses a difficult challenge as only few susceptibility genes with high penetrance identified, namely, BRCA1 and BRCA2. It now suspected that majority hereditary cancers are caused by various combinations several moderate- and/or low-penetrance genes. Recent developments research methodologies conceptual frameworks within biology revolutionized study This systems approach, which emphasizes holistic biological systems, referred to generally “omics.” A decade omics has led identification many new therapeutic targets biomarkers, allowing accurate earlier diagnosis treatment wide spectrum diseases collectively Here we review contributions fields cancer, genomics, transcriptomics, proteomics, metabolomics.