Assessment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma by Absolute Lymphocyte Counts in 2,126 Patients: 20 Years of Experience at The University of Texas M.D. Anderson Cancer Center

摘要: Purpose Chronic lymphocytic leukemia (CLL) and small lymphoma (SLL) are currently considered the same entity, but controversy remains over whether CLL SLL should be treated similarly. We assessed characteristics of patients with differ in ways other than absolute lymphocyte count (ALC) evaluated treatment outcomes prognostic factors. Methods searched electronic database for or who presented to The University Texas M.D. Anderson Cancer Center (Houston, TX) between 1985 2005. reviewed patient records determine presenting characteristics, treatment, clinical outcomes. Cox models using training validation sets resampling methods were used develop a model predicting survival. Results Among 2,126 consecutive CLL/SLL patients, 312 (15%) had ALC less 5 × 109/L. Patients 109/L lower rates cytogenetic abnormalities (P = .0002) higher CD38-positive resul...