Hepatic Injury from Chronic Hypervitaminosis a Resulting in Portal Hypertension and Ascites

摘要: Abstract Chronic hypervitaminosis A was diagnosed in two patients who were initially seen because of ascites and clinical signs cirrhosis. Histologic examination liver-biopsy material revealed perisinusoidal fibrosis, central-vein sclerosis focal congestion associated with lipid-storage cells. Vitamin fluorescence found on frozen sections, direct assay tissue substantial increases vitamin content (1700 to 2200 μg per gram wet liver). Electron microscopy demonstrated an increase basement-membrane-like collagen within the space association lipid-filled Ito The nature this unusual lesion suggested that it might obstruct hepatic blood flow, result considerable parenchymal-cell atrophy lead portal hypertension. These findings suggest chronic ingestion large amounts stimulates fibrogenesis results a disorder function resembling (N Engl J Med 291:435–...