The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target.
作者： Miles D. Houslay
关键词: Acetylation 、 Histone 、 Gene isoform 、 Vascular smooth muscle 、 Pharmacology 、 Internal medicine 、 Extracellular matrix 、 Stroke 、 Endocrinology 、 Biology 、 Pharmacotherapy 、 Phenotype
摘要: In this issue, Tilley and Maurice (p. 596) show that differentiation of vascular smooth muscle cells to a proliferative phenotype is associated with profound up-regulation specific phosphodiesterase-4 (PDE4) isoforms because increased histone acetylation. The PDE4 activity seen as preventing cAMP from inhibiting the enhanced proliferation, migration, production extracellular matrix in activated VSMC. This Perspective examines proposal selective inhibition PDE4D1/2 could find use adjunctive pharmacotherapy after percutaneous coronary interventions and, addition, discusses recent genetic evidence PDE4D7 may provide therapeutic target stroke.
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