Cerebrospinal Fluid Enzymes in Neurological Disease

摘要: The recognition of enzymes in cerebrospinal fluid (CSF) began with reports acid and alkaline phosphatase activity 193865,117 ribonuclease (RNase) 1946.211 Numerous have subsequently been sought CSF, the majority assayed neurological diseases. Activities most examined lower normal CSF than disease, they also blood.242a It thus seems inescapable that their major source is derived from serum enter at choroid plexus or via permeability blood-CSF blood-brain barrier. Enzymes originate indigenous cells central nervous system (CNS) peripheral (PNS) (from proximal portions cranial nerves spinal roots) infiltrating (leukocytes) reached this extracellular compartment. In instances, relative contribution these alteration disease not fully understood.