Lithium Chloride Modulates Adipogenesis and Osteogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells.
作者： Linjun Tang , Yu Chen , Fuxing Pei , Hui Zhang
DOI: 10.1159/000430340
关键词: Hedgehog signaling pathway 、 Chemistry 、 Internal medicine 、 Lithium chloride 、 Cell biology 、 Bone marrow 、 Oil Red O 、 Endocrinology 、 Adipogenesis 、 Cellular differentiation 、 Wnt signaling pathway 、 Mesenchymal stem cell
摘要: Background/Aims: Lithium chloride (LiCl) has long been used as a psychiatric medication; however, its role in the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) remains largely unknown. The aim this study is to explore effect LiCl on BMSCs. Methods: roles osteogenic and adipogenic processes were observed using alizarin red staining oil O staining, respectively. effects Wnt Hedgehog (Hh) pathways investigated. Results: Our data showed that effectively promoted osteogenesis inhibited adipogenesis by simultaneously affecting Hh pathways. Conclusion: These results suggest influences BMSCs directly through thus may be candidate drug for treatment osteoporosis.
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