The Inositol Phosphatase SHIP-1 Inhibits NOD2-Induced NF-κB Activation by Disturbing the Interaction of XIAP with RIP2
作者： Claude Condé , Xavier Rambout , Marielle Lebrun , Aurore Lecat , Emmanuel Di Valentin
DOI: 10.1371/JOURNAL.PONE.0041005
关键词: Biology 、 XIAP 、 NFKB1 、 Mediator 、 Signal transduction 、 Proinflammatory cytokine 、 Small interfering RNA 、 Downregulation and upregulation 、 Molecular biology 、 Transcription factor 、 Cell biology
摘要: SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, has been described as important regulator of immune functions. Here, we characterize a new inhibitory function for NOD2 signaling. crucial cytoplasmic bacterial sensor that activates proinflammatory and antimicrobial responses upon invasion. We observed decreases NOD2-induced NF-κB activation macrophages. This negative regulation relies on its interaction with XIAP. Indeed, XIAP essential mediator signaling pathway enables proper Upon activation, C-terminal proline rich domain (PRD) interacts XIAP, thereby disturbing between RIP2 order to decrease
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core.ac.uk 参考文章(54)
S. Tridandapani, H. Phee, L. Shivakumar, T.W. Kelley, K.M. Coggeshall, Role of SHIP in FcgammaRIIb-mediated inhibition of Ras activation in B cells. Molecular Immunology. ,vol. 35, pp. 1135- 1146 ,(1998) , 10.1016/S0161-5890(98)00097-2
S Tridandapani, J R LaDine, C L Anderson, S Garber, K M Coggeshall, M Pradhan, Protein Interactions of Src Homology 2 (SH2) Domain-Containing Inositol Phosphatase (SHIP): Association with Shc Displaces SHIP from FcγRIIb in B Cells Journal of Immunology. ,vol. 162, pp. 1408- 1414 ,(1999)
C. S. Duckett, V. E. Nava, R. W. Gedrich, R. J. Clem, J. L. Van Dongen, M. C. Gilfillan, H. Shiels, J. M. Hardwick, C. B. Thompson, A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. The EMBO Journal. ,vol. 15, pp. 2685- 2694 ,(1996) , 10.1002/J.1460-2075.1996.TB00629.X
Jean-Pierre Hugot, Mathias Chamaillard, Habib Zouali, Suzanne Lesage, Jean-Pierre Cézard, Jacques Belaiche, Sven Almer, Curt Tysk, Colm A. O'Morain, Miquel Gassull, Vibeke Binder, Yigael Finkel, Antoine Cortot, Robert Modigliani, Pierre Laurent-Puig, Corine Gower-Rousseau, Jeanne Macry, Jean-Frédéric Colombel, Mourad Sahbatou, Gilles Thomas, Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature. ,vol. 411, pp. 599- 603 ,(2001) , 10.1038/35079107
Joan Ní Gabhann, Rowan Higgs, Kiva Brennan, Warren Thomas, Jacqueline E. Damen, Nadia Ben Larbi, Gerald Krystal, Caroline A. Jefferies, Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production Journal of Immunology. ,vol. 184, pp. 2314- 2320 ,(2010) , 10.4049/JIMMUNOL.0902589
Yasunori Ogura, Denise K. Bonen, Naohiro Inohara, Dan L. Nicolae, Felicia F. Chen, Richard Ramos, Heidi Britton, Thomas Moran, Reda Karaliuskas, Richard H. Duerr, Jean-Paul Achkar, Steven R. Brant, Theodore M. Bayless, Barbara S. Kirschner, Stephen B. Hanauer, Gabriel Nuñez, Judy H. Cho, A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature. ,vol. 411, pp. 603- 606 ,(2001) , 10.1038/35079114
Hridayesh Prakash, Marco Albrecht, Daniel Becker, Tanja Kuhlmann, Thomas Rudel, Deficiency of XIAP Leads to Sensitization for Chlamydophila pneumoniae Pulmonary Infection and Dysregulation of Innate Immune Response in Mice Journal of Biological Chemistry. ,vol. 285, pp. 20291- 20302 ,(2010) , 10.1074/JBC.M109.096297
Laura D. Bauler, Colin S. Duckett, Mary X. D. O'Riordan, XIAP Regulates Cytosol-Specific Innate Immunity to Listeria Infection PLoS Pathogens. ,vol. 4, pp. e1000142- ,(2008) , 10.1371/JOURNAL.PPAT.1000142
Mads Gyrd-Hansen, Maurice Darding, Maria Miasari, Massimo M. Santoro, Lars Zender, Wen Xue, Tencho Tenev, Paula C.A. da Fonseca, Marketa Zvelebil, Janusz M. Bujnicki, Scott Lowe, John Silke, Pascal Meier, IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis. Nature Cell Biology. ,vol. 10, pp. 1309- 1317 ,(2008) , 10.1038/NCB1789
W.M. Kavanaugh, D.A. Pot, S.M. Chin, M. Deuter-Reinhard, A.B. Jefferson, F.A. Norris, F.R. Masiarz, L.S. Cousens, P.W. Majerus, Lewis T. Williams, Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 Current Biology. ,vol. 6, pp. 438- 445 ,(1996) , 10.1016/S0960-9822(02)00511-0