Consistent mutation status within histologically heterogeneous lung cancer lesions
作者： Johanna Sofia Margareta Mattsson , Juliana Imgenberg-Kreuz , Karolina Edlund , Johan Botling , Patrick Micke
DOI: 10.1111/J.1365-2559.2012.04245.X
关键词: EGFR inhibitors 、 Epidermal growth factor receptor 、 Lung cancer 、 Microdissection 、 Mutation 、 Oncology 、 KRAS 、 Biology 、 Internal medicine 、 Cancer 、 Mutation testing
摘要: Mattsson J S M, Imgenberg-Kreuz J, Edlund K, Botling & Micke P (2012) Histopathology 61, 744–748 Consistent mutation status within histologically heterogeneous lung cancer lesions Aims: Activating epidermal growth factor receptor (EGFR) and KRAS mutations characterize molecular subgroups of non-small-cell (NSCLC) with a strong predictive value for response to EGFR inhibitor therapy. However, the temporal occurrence clonal stability these during course progression are debated. The aim this study was presence in different areas primary NSCLC lesions. Methods results: Formalin-fixed paraffin-embedded specimens from six cases five were selected pool resected patients. From each tumour, three morphologically distinct manually microdissected analysed mutations. results demonstrated consistent histological all tumours. Conclusions: support concept that activating oncogenic events consistently present throughout tumour independently heterogeneity. Thus, diagnostics, any part is likely be representative testing.
sci-hub.se 参考文章(21)
Keith M Kerr, Personalized medicine for lung cancer: new challenges for pathology Histopathology. ,vol. 60, pp. 531- 546 ,(2012) , 10.1111/J.1365-2559.2011.03854.X
Hiroaki Kitano, Cancer as a robust system: implications for anticancer therapy. Nature Reviews Cancer. ,vol. 4, pp. 227- 235 ,(2004) , 10.1038/NRC1300
Patricia J T A Groenen, Willeke A M Blokx, Coos Diepenbroek, Lambert Burgers, Franco Visinoni, Pieter Wesseling, Johan H J M van Krieken, Preparing pathology for personalized medicine: possibilities for improvement of the pre-analytical phase Histopathology. ,vol. 59, pp. 1- 7 ,(2011) , 10.1111/J.1365-2559.2010.03711.X
Atsushi Ochiai, Tomoyuki Yokose, Katashi Fukao, Tatsuya Oda, Yasuyuki Aoyagi, Yuko Minami, Yukio Morishita, Tatsuo Iijima, Masayuki Noguchi, Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma Cancer Research. ,vol. 61, pp. 7950- 7954 ,(2001)
Sylvie Lantuéjoul, Dimitri Salameire, Caroline Salon, Elisabeth Brambilla, Pulmonary preneoplasia--sequential molecular carcinogenetic events. Histopathology. ,vol. 54, pp. 43- 54 ,(2009) , 10.1111/J.1365-2559.2008.03182.X
Patrick Micke, Tone Bjørnsen, Stefan Scheidl, Sara Strömberg, Jean-Baptiste Demoulin, Fredrik Ponten, Arne Östman, Per Lindahl, Christer Busch, A fluid cover medium provides superior morphology and preserves RNA integrity in tissue sections for laser microdissection and pressure catapulting. The Journal of Pathology. ,vol. 202, pp. 130- 138 ,(2004) , 10.1002/PATH.1496
Magnus Sundström, Karolina Edlund, Monica Lindell, Bengt Glimelius, Helgi Birgisson, Patrick Micke, Johan Botling, KRAS analysis in colorectal carcinoma: Analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice BMC Cancer. ,vol. 10, pp. 660- 660 ,(2010) , 10.1186/1471-2407-10-660
Keith M Kerr, Pulmonary adenocarcinomas: classification and reporting. Histopathology. ,vol. 54, pp. 12- 27 ,(2009) , 10.1111/J.1365-2559.2008.03176.X
Vince D. Cataldo, Don L. Gibbons, Román Pérez-Soler, Alfonso Quintás-Cardama, Treatment of non-small-cell lung cancer with erlotinib or gefitinib. The New England Journal of Medicine. ,vol. 364, pp. 947- 955 ,(2011) , 10.1056/NEJMCT0807960
William D Travis, Elisabeth Brambilla, Masayuki Noguchi, Andrew G Nicholson, Kim R Geisinger, Yasushi Yatabe, David G Beer, Charles A Powell, Gregory J Riely, Paul E Van Schil, Kavita Garg, John HM Austin, Hisao Asamura, Valerie W Rusch, Fred R Hirsch, Giorgio Scagliotti, Tetsuya Mitsudomi, Rudolf M Huber, Yuichi Ishikawa, James Jett, Montserrat Sanchez-Cespedes, Jean-Paul Sculier, Takashi Takahashi, Masahiro Tsuboi, Johan Vansteenkiste, Ignacio Wistuba, Pan-Chyr Yang, Denise Aberle, Christian Brambilla, Douglas Flieder, Wilbur Franklin, Adi Gazdar, Michael Gould, Philip Hasleton, Douglas Henderson, Bruce Johnson, David Johnson, Keith Kerr, Keiko Kuriyama, Jin Soo Lee, Vincent A Miller, Iver Petersen, Victor Roggli, Rafael Rosell, Nagahiro Saijo, Erik Thunnissen, Ming Tsao, David Yankelewitz, None, International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma Journal of Thoracic Oncology. ,vol. 6, pp. 244- 285 ,(2011) , 10.1097/JTO.0B013E318206A221