KRAS analysis in colorectal carcinoma: Analytical aspects of Pyrosequencing and allele-specific PCR in clinical practice
作者： Magnus Sundström , Karolina Edlund , Monica Lindell , Bengt Glimelius , Helgi Birgisson
关键词: Polymerase chain reaction 、 Cancer research 、 Surgical oncology 、 Colorectal cancer 、 Adenocarcinoma 、 Variants of PCR 、 KRAS 、 Epidermal growth factor receptor 、 Genetic testing 、 Medicine 、 Pathology
摘要: Background Epidermal growth factor receptor inhibitor therapy is now approved for treatment of metastatic colorectal carcinomas (CRC) in patients with tumors lacking KRAS mutations. Several procedures to detect mutations have been developed. However, the analytical sensitivity and specificity these assays on routine clinical samples are not yet fully characterised.
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