Classical Conditioning Differences Associated With Chronic Pain: A Systematic Review

摘要: Abstract Prominent clinical models of chronic pain propose a fundamental role classical conditioning in the development pain-related disability. If is key to this process, then people with may show different response conditioned stimuli than healthy control subjects. We set out determine whether case by undertaking comprehensive and systematic review literature. To identify studies comparing between subjects, databases MEDLINE, PsychINFO, PsychARTICLES, Scopus, CINAHL were searched using words medical subject headings consistent ‘classical conditioning’ ‘pain.’ Articles included when: 1) pain-free groups included, 2) differential design was used. The search revealed 7 investigating differences participants. involved total 129 (fibromyalgia syndrome, spinal pain, hand irritable bowel syndrome), 104 Outcomes indices such as unconditioned stimulus (US) expectancy contingency awareness, self-report physiological measures fear, evaluative judgements pleasantness, muscular cortical responses. Because variability outcomes, meta-analyses maximum 4 studies. People tended reduced learning flatter generalization gradients respect US fear-potentiated eyeblink startle Some showed propensity for greater responses perceptions unpleasantness pain-associated cues, relative cues. Perspective preliminary evidence that exhibit less fear learning. This characteristic contribute widespread fear-avoidance behavior. assumption altered be predisposing or maintaining factor remains verified.