Fear-learning deficits in subjects with fibromyalgia syndrome?

摘要: BACKGROUND: Fibromyalgia syndrome (FMS) is frequently associated with psychiatric conditions, particularly anxiety. Deficits in contingency learning during fear conditioning have been hypothesized to increase anxiety and, consequently, pain sensation susceptible individuals. The goal of this study was examine the relationship between and experience subjects FMS rheumatoid arthritis (RA). METHODS: Fourteen female subjects, 14 age-matched RA healthy controls (HCs) were included a fear-conditioning experiment. conditioned stimulus (CS) consisted visual signs, unconditioned (US) thermal stimuli. CS- predicted low-temperature exposure (US), while CS+ followed by low or high temperature. RESULTS: In group, only 50% aware US-CS contingency, whereas 86% all HCs contingency. induced more than HCs. As expected, experienced as less painful after these subjects. did not show such adaptive conditioning. effects type CS on heart rate changes significant but unaware CONCLUSIONS: Contingency deficits represent potentially promising specific, largely unstudied, psychopathological factor FMS. may sensation. These findings potential contribute development novel therapeutic approaches for