Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.
作者： Julien Viaud , Frédéric Boal , Hélène Tronchère , Frédérique Gaits-Iacovoni , Bernard Payrastre
关键词: Cytoskeleton 、 Cell biology 、 Phosphatidylinositol 5-phosphate 、 Regulator 、 Cell nucleus 、 Phosphatidylinositol 、 PIKFYVE 、 Phosphatidylinositol Phosphates 、 Biology 、 Cell membrane
摘要: Phosphatidylinositol 5-phosphate (PtdIns5P), the least characterized among three phosphatidylinositol monophosphates, is emerging as a bioactive lipid involved in control of several cellular functions. Similar to PtdIns3P, it present low amounts mammalian cells, and can be detected at plasma membrane endomembranes well nucleus. Changes PtdIns5P levels are observed cells following specific stimuli or stresses, human diseases. Recently, contribution enzymes such PIKfyve, myotubularins, type II PtdInsP-kinases metabolism has gained strong experimental support. Here, we provide picture from recent studies showing how this generated act regulator cytoskeleton dynamics, modulator gene expression. We briefly summarize current methods tools for studying PtdIns5P, discuss integrate coordinate different functions spatiotemporal manner.
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