Phosphoinositides: Important lipids in the coordination of cell dynamics.

摘要: By interacting specifically with proteins, phosphoinositides organize the spatiotemporal formation of protein complexes involved in control intracellular signaling, vesicular trafficking and cytoskeleton dynamics. A set specific kinases phosphatases ensures production, degradation inter-conversion to achieve a high level precision regulation cellular dynamics coordinated by these lipids. The direct involvement enzymes cancer, genetic or infectious diseases, recent arrival inhibitors targeting phosphoinositide clinic, emphasize importance lipids their metabolism biomedical field.