Two functionally distinct pools of Src kinases for PDGF receptor signalling.
作者： L. Veracini , M. Franco , A. Boureux , V. Simon , S. Roche
DOI: 10.1042/BST0331313
关键词: Proto-oncogene tyrosine-protein kinase Src 、 Kinase 、 Compartmentalization (psychology) 、 Cell growth 、 Platelet-derived growth factor receptor 、 Biology 、 Tyrosine kinase 、 Cell biology 、 Growth factor 、 Cytoplasm
摘要: The cytoplasmic tyrosine kinases of the Src family (SFK) play important roles in cell responses induced by growth factors, including growth, survival and migration. Here, we review how SFK participate PDGF (platelet-derived factor) receptor signalling leading to DNA synthesis actin assembly. Furthermore, evidence for a spatial compartmentalization is also discussed.
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