Fyn is involved in angiotensin II type 2 receptor-induced neurite outgrowth, but not in p42/p44mapk in NG108-15 cells
作者： M.-O. Guimond , Claude Roberge , N. Gallo-Payet
DOI: 10.1016/J.MCN.2010.06.011
关键词:
摘要: Abstract In NG108-15 cells, activation of p42/p44mapk is essential for induction neurite outgrowth by angiotensin II (Ang II) type 2 receptor (AT2). The aim was to verify whether Fyn, a member the Src family kinases (SFK), involved in induced AT2 activation. Preincubation cells with PP1, general inhibitor SKF, decreased Rap1 and abolished TrkA Ang or agonist, CGP42112A. were transfected Fyn-WT Fyn-DN expressing vector. sufficient induce outgrowth, although transfection elongation. However, form failed affect TrkA, II. Thus, SKF activity required achieve AT2-induced p42/p44mapk, Fyn receptor-induced but not signaling leading
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