Heterogeneity of Subcellular Localization of p53 Protein in Human Glioblastomas

摘要: Abstract Immunohistochemical analysis of the p53 protein in human glioblastomas with known genetic profiles mutations and allele losses on chromosome 17p demonstrated a heterogeneous pattern subcellular compartmentalization protein. Tumors single wild type copy gene but allelic deletions exhibit nuclear and/or cytoplasmic accumulation , whereas tumors both copies no 17 do not accumulate p53. Glioblastomas one normal mutated distal to p53, other hand, show predominantly staining, probably originating from Furthermore, same codon display quite different intracellular distribution suggesting that, addition genotype microenvironment particular tumor is important determining localization The costs publication this article were defrayed part by payment page charges. This must therefore be hereby marked advertisement accordance 18 U.S.C. Section 1734 solely indicate fact.