Selective distribution of matrix metalloproteinase-3 (MMP-3) in Alzheimer's disease brain.
作者： Yasumasa Yoshiyama , Masato Asahina , Takamichi Hattori
DOI: 10.1007/PL00007428
关键词: Pathogenesis 、 Matrix metalloproteinase 、 White matter 、 Human brain 、 Hippocampus 、 Central nervous system 、 Biology 、 Pathology 、 Alzheimer's disease 、 Senile plaques
摘要: A growing amount of evidence indicates that matrix metalloproteinases (MMPs) may play an important role in the pathogenesis Alzheimer’s disease (AD). Stromelysin-1 (MMP-3) plays a central activating latent-type MMPs, which are originally secreted as proenzymes. We examined MMP-3 immunoreactivity brains patients who had suffered from and those neurologically normal persons. The interstitium between myelinated axons astrocytes white matter all brain tissues, senile plaques gray with AD were stained monoclonal antibody to MMP-3. Comparison number against parietal cortex hippocampus showed fewer hippocampus. selective distribution human suggests might AD, especially degradation β-amyloid protein.
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