Evaluation of the Neuropad sudomotor function test as a screening tool for polyneuropathy in the elderly population with diabetes and pre-diabetes: the KORA F4 survey.

摘要: Background Neuropad is a novel indicator test for sudomotor dysfunction, which has not been validated as screening tool in population-based study. This study aimed to evaluate the utility of Neuropad distal symmetric polyneuropathy among elderly subjects with diabetes and pre-diabetes general population. Methods Eligible aged 61–82 years (n = 940) from KORA F4 survey were examined, 201 whom had 231 (WHO 1999 criteria). Polyneuropathy was defined by Michigan Neuropathy Screening Instrument (MNSI) score >3. Results Polyneuropathy diagnosed 60 (29.9%) 45 (19.5%) pre-diabetes, respectively (p = 0.013). The sensitivity negative predictive value (reading time: 10 min) diagnosis moderately high, reaching 76.7% 78.1% 57.8% 76.5% those respectively. Conversely, specificity positive rather low: 35.5% 33.6% diabetic individuals 33.3% 17.3% Use >2 cut-off MNSI combined monofilament examination did improve diagnostic performance Neuropad. Conclusions In population reasonable but low polyneuropathy. It useful simple inexpensive screen exclude desired, while its implies that longer reading time merits consideration. Copyright © 2012 John Wiley & Sons, Ltd.