Short term therapeutic efficacy of camel milk Vis-À-Vis buffalo milk in Alloxan® induced diabetic rabbits
作者： Farrah Deeba , Anas Sarwar Qureshi , Muhammad Kamran , Azam Farooq , Naeem Faisal
DOI: 10.1007/S40200-020-00580-7
关键词: Camel milk 、 Medicine 、 Renal function 、 Endocrinology 、 Creatinine 、 Therapeutic effect 、 Internal medicine 、 Glibenclamide 、 Diabetes mellitus 、 Hematology 、 Alloxan
摘要: This is the first comparative report that demonstrates comparison of anti-hyperglycemic activity camel milk, buffalo milk and synthetic drugs in induced diabetic rabbits. Five groups (n = 8) rabbits containing placebo (G1) hyperglycemic (Alloxan® administered intravenously) including control (G2), treated @40 ml/kg (G3), (G4) glibenclamide (Glicon®) @10 mg/kg (G5) orally for 60 days. Collection blood was done hematology biochemical analysis. Renal hepatic tissue sections were processed by routine paraffin technique diabetes-induced histopathological changes anti-diabetic milk. Diabetes deleteriously (P ≤ 0.05) affects all studied parameters. A significant recovery seen diabetogenic hematological (RBC, MCV, Hb, MCH) serological parameters (AST, ALT, creatinine, BUN, TPs, TOS) with treatment. Camel decreased glucose level more significantly (P < 0.01) than but renal function. Microscopic observations demonstrated recovered altered histology liver kidneys towards normal. The results indicate has a potential therapeutic effect treatment hyperglycemia plays role its management as well reduces risk diabetes-related complications compared to
springer.com
scilit.net参考文章(23)
John D. Bancroft, Marilyn Gamble, Theory and Practice of Histological Techniques ,(1990)
Gehad Ramadan El-Sayed, Esraa Tantawy, El-Said El-Sherbini El-Said, Effect of Camel Milk on Oxidative Stresses in Experimentally Induced Diabetic Rabbits Veterinary Research Forum. ,vol. 1, pp. 30- 43 ,(2010)
Stefano Zucchini, Andrea E. Scaramuzza, Riccardo Bonfanti, Pietro Buono, Francesca Cardella, Vittoria Cauvin, Valentino Cherubini, Giovanni Chiari, Giuseppe d’Annunzio, Anna Paola Frongia, Dario Iafusco, Giulio Maltoni, Ippolita Patrizia Patera, Sonia Toni, Stefano Tumini, Ivana Rabbone, , A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes Experimental Diabetes Research. ,vol. 2016, pp. 1- 6 ,(2016) , 10.1155/2016/5719470
Omar A. Al haj, Hamad A. Al Kanhal, Compositional, technological and nutritional aspects of dromedary camel milk International Dairy Journal. ,vol. 20, pp. 811- 821 ,(2010) , 10.1016/J.IDAIRYJ.2010.04.003
D. T. Peterson, W. C. Greene, G. M. Reaven, Effect of Experimental Diabetes Mellitus on Kidney Ribosomal Protein Synthesis Diabetes. ,vol. 20, pp. 649- 654 ,(1971) , 10.2337/DIAB.20.10.649
A. Yateem, M.T. Balba, T. Al-Surraya, B. Al-Mutairi, R. Al-Daher, ISOLATION OF LACTIC ACID BACTERIA WITH PROBIOTIC POTENTIAL FROM CAMEL MILK International Journal of Dairy Science. ,vol. 3, pp. 194- 199 ,(2008) , 10.3923/IJDS.2008.194.199
B Ragavan, S Krishnakumari, Effect of T. arjuna stem bark extract on histopathology of liver, kidney and pancreas of alloxan-induced diabetic rats African Journal of Biomedical Research. ,vol. 9, ,(2009) , 10.4314/AJBR.V9I3.48904
Ochuko L Erukainure, Osaretin AT Ebuehi, Folasade O Adeboyejo, Muhammad Aliyu, Gloria N Elemo, None, Hematological and biochemical changes in diabetic rats fed with fiber-enriched cake Journal of Acute Medicine. ,vol. 3, pp. 39- 44 ,(2013) , 10.1016/J.JACME.2013.03.001
Ozcan Erel, A novel automated method to measure total antioxidant response against potent free radical reactions Clinical Biochemistry. ,vol. 37, pp. 112- 119 ,(2004) , 10.1016/J.CLINBIOCHEM.2003.10.014
Amal Bakr Shori, Camel milk as a potential therapy for controlling diabetes and its complications: A review of in vivo studies Journal of Food and Drug Analysis. ,vol. 23, pp. 609- 618 ,(2015) , 10.1016/J.JFDA.2015.02.007