Elevated serum neopterin levels in atherosclerosis

摘要: Plasma levels of neopterin were determined in patients with different clinical stages atherosclerosis. Non-hospitalized atherosclerosis had serum and plasma within the normal range assay (6 +/- 2 nM). These values not significantly from those reported for healthy blood donors (5 In contrast, about 50% (29 out 61) hospitalized undergoing conservative or surgical therapy levels, which exceeded (greater than 10 nM) up to 10-fold. The two groups differ on a significance level P less 0.01. For further evaluation subgrouped according levels. subgroup elevated higher Frederickson types overrepresented compared Type 4 differed without pathological changes lipoprotein (P 0.05). Only 3 suffered minimal skin necrosis, them Significantly more peripheral artery occlusions central arteries All other criteria used comparison (sex, age, smoking, antioxidant status, diabetes, hypertension, adipositas, hyperuricemia) did vary both subgroups. data indicate that might be valuable parameter activity staging therapeutic follow atherosclerotic patients. Additionally, an involvement nonspecific immune system atherogenesis is suggested by increased concentrations.