Intrathecal production of neopterin in aseptic meningo-encephalitis and multiple sclerosis

摘要: Neopterin levels in cerebrospinal fluid (CSF) and serum were measured with a sensitive radioimmunoassay patients multiple sclerosis (MS), aseptic meningo-encephalitis (AM), other mostly non-inflammatory neurological diseases, controls tension headache or psychoneurosis. Elevated of neopterin found CSF most during acute phase AM, normalization after clinical recovery. The elevation was not reflected serum. Only four 24 MS patients--three them examined exacerbation--had slight all had normal levels. correlated mononuclear cell count. observed inflammatory CNS diseases despite low numbers compared to blood might reflect high activation level cells locally the CNS. is valuable marker cellular immune response.