Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors

摘要: The invention concerns a method of inhibiting both thromboxane synthetase and cyclic-AMP phosphodiesterase in mammal having disease characterized by elevated levels or an imbalance prostacyclin/thromboxane with compound the formula: ##STR1## pharmaceutically acceptable acid addition salt ester thereof, wherein: X is chosen from group consisting of: ##STR2## covalent bond which R1 H, alkyl 1-6 carbon atoms, optionally substituted phenyl lower alkyl, when R2 H OH, taken together represent oxo, alkylidene atoms benzylidene; R3 R4 are either cis trans to each other, bond; n integer 0-3; Het 1-imidazolyl 3-pyridyl; dotted line represents optional bond.