Expression of a receptor for IgM by human T cells in vitro.
作者： L. Moretta , M. Ferrarini , Maria Laura Durante , Maria Cristina Mingari
关键词: Receptor 、 Molecular biology 、 Rosette formation 、 Biology 、 Peripheral blood 、 In vitro 、 B cell 、 Rosette (botany) 、 Igm antibody 、 Antibody
摘要: The capacity of human peripheral blood lymphocytes (PBL) to bind antigen-IgG antibody (EA(IgG)) and antigen-IgM (EA(IgM)) complexes was investigated using a rosette technique with ox erythrocytes coated rabbit IgG or IgM antibody. It found that while EA(IgG)-rosette-forming cells (RFC) were detected on PBL freshly drawn from normal individuals, EA(IgM)-RFC present only in suspensions kept culture for 24 h media supplemented sera containing very low no amounts IgM. Experiments simultaneous detection EA(IgG)-RFC other membrane markers T B together experiments purified cell populations indicated formed by both cells, capable EA(IgM) formation. The specificity the receptors determined studying inhibitory assay. receptor inhibited not IgM, reverse true
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