Inhibition of osteoclastic motility by prostaglandins I2, E1, E2 and 6-oxo-E1.

摘要: We have recently found that calcitonin (CT), a hormone which inhibits osteoclastic bone resorption, completely abolishes the normally intense cytoplasmic motility of isolated osteoclasts. Here we report prostaglandin (PG)I2, PGE1, PGE2 and 6-oxo-PGE1 cause an identical change in behaviour to induced by CT. The order potency was PGI2 greater than PGE1 PGE2. that, unlike CT causes prolonged immotility osteoclasts, effect these PGs transient. transient nature inhibition not caused their decay or inactivation, nor it due production cultures stimulator osteoclast motility. Osteoclasts refractory one PG were also less sensitive others, but showed no loss sensitivity CT, suggesting share common receptor system, distinct from for PGs, like appear operate increasing cyclic AMP level response osteoclasts shared use as second messenger, suggest act directly on inhibit resorption cells. Osteoblasts are known make osteoblasts them agents local control resorption. Paradoxically, when added organ culture they stimulate Like PTH increase osteoblastic levels, adding may be direct followed sustained PTH-like stimulation through osteoblasts. This mechanism account seen inflammatory malignant disease.