The Effect of Infective Exacerbations on Sleep and Neurobehavioral Function in Cystic Fibrosis
作者： Catherine J. Dobbin , Delwyn Bartlett , Kerri Melehan , Ronald R. Grunstein , Peter T. P. Bye
DOI: 10.1164/RCCM.200409-1244OC
关键词: Anesthesia 、 Sleep onset 、 Hypercapnia 、 Neurological disorder 、 Hypoxemia 、 Surgery 、 Medicine 、 Cystic fibrosis 、 Sleep disorder 、 Exacerbation 、 Intensive care
摘要: Rationale: Adults with cystic fibrosis (CF) are susceptible to hypoxemia, hypercapnia, arousal from sleep, and neurobehavioral impairment. Objectives: We hypothesized that pulmonary exacerbations would adversely affect sleep performance. Methods: Patients (cases) had studies testing before after inpatient intravenous therapy. stable CF underwent the same procedures (control subjects). Measurements Main Results: When clinically stable, cases control subjects similar lung function, intelligence, body mass index. Among cases, treatment of an exacerbation improved quality life, mood, sleepiness, activation. Cases spent more time awake onset (p = 0.02), less in REM 0.03), were hypoxemic than when unwell. The severity hypoxemia correlated function. On admission, slower throughput se...
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