Photodynamic activity of aloe-emodin induces resensitization of lung cancer cells to anoikis
作者： Hong-Zin Lee , Wen-Hui Yang , Mann-Jen Hour , Chi-Yu Wu , Wen-Huang Peng
DOI: 10.1016/J.EJPHAR.2010.08.033
关键词: Anoikis 、 Cell biology 、 Photodynamic therapy 、 Immunology 、 Biology 、 Kinase 、 Aloe emodin 、 Programmed cell death 、 Cell culture 、 Mitochondrial permeability transition pore 、 Regulation of gene expression
摘要: Aloe-emodin was found to be a photosensitizer and possess anti-tumor activity. However, the detailed mechanism underlying biological effects of aloe-emodin remains unknown. In this study, we explored mechanisms photocytotoxicity induced by in lung cancer H460 cells. According results photoactivated aloe-emodin-induced disruption cytoskeleton, verify that with irradiation induces anoikis Photosensitized is associated protein expression α-actinin mitogen-activated (MAP) kinase members. rapid opening mitochondrial permeability transition pore change apoptosis-related were involved cell death. We also demonstrated mediated through intrinsic extrinsic death pathways caspase-dependent manner
elsevier.com
sci-hub.se 参考文章(30)
Harsh Pal Bais, Ramarao Vepachedu, Christopher B. Lawrence, Frank R. Stermitz, Jorge M. Vivanco, Molecular and Biochemical Characterization of an Enzyme Responsible for the Formation of Hypericin in St. John's Wort (Hypericum perforatum L.) Journal of Biological Chemistry. ,vol. 278, pp. 32413- 32422 ,(2003) , 10.1074/JBC.M301681200
Hong-Zin Lee, Shih-Lan Hsu, Mei-Chun Liu, Chun-Hsiung Wu, Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma European Journal of Pharmacology. ,vol. 431, pp. 287- 295 ,(2001) , 10.1016/S0014-2999(01)01467-4
Emily H-Y Cheng, David G Kirsch, Rollie J Clem, Rajani Ravi, Michael B Kastan, Atul Bedi, Kazuyoshi Ueno, J Marie Hardwick, Conversion of Bcl-2 to a Bax-like Death Effector by Caspases Science. ,vol. 278, pp. 1966- 1968 ,(1997) , 10.1126/SCIENCE.278.5345.1966
Eric A Swan, Samar A Jasser, Floyd C Holsinger, Dao Doan, Cora Bucana, Jeffrey N Myers, Acquisition of anoikis resistance is a critical step in the progression of oral tongue cancer. Oral Oncology. ,vol. 39, pp. 648- 655 ,(2003) , 10.1016/S1368-8375(03)00049-6
C. Soldani, A. C. Croce, M. G. Bottone, A. Fraschini, M. Biggiogera, G Bottiroli, C. Pellicciari, Apoptosis in tumour cells photosensitized with Rose Bengal acetate is induced by multiple organelle photodamage Histochemistry and Cell Biology. ,vol. 128, pp. 485- 495 ,(2007) , 10.1007/S00418-007-0333-3
James W. Rocco, David Sidransky, p16(MTS-1/CDKN2/INK4a) in Cancer Progression Experimental Cell Research. ,vol. 264, pp. 42- 55 ,(2001) , 10.1006/EXCR.2000.5149
Anthony J. Valentijn, Anthony D. Metcalfe, Jane Kott, Charles H. Streuli, Andrew P. Gilmore, Spatial and temporal changes in Bax subcellular localization during anoikis. Journal of Cell Biology. ,vol. 162, pp. 599- 612 ,(2003) , 10.1083/JCB.200302154
S. M. A. ZOBAYED, F. AFREEN, E. GOTO, T. KOZAI, Plant-environment interactions: Accumulation of hypericin in dark glands of Hypericum perforatum. Annals of Botany. ,vol. 98, pp. 793- 804 ,(2006) , 10.1093/AOB/MCL169
RWK Wu, ESM Chu, CMN Yow, JY Chen, None, Photodynamic effects on nasopharyngeal carcinoma (NPC) cells with 5-aminolevulinic acid or its hexyl ester Cancer Letters. ,vol. 242, pp. 112- 119 ,(2006) , 10.1016/J.CANLET.2005.10.048
H.H. Kampinga, J.F. Brunsting, G.J.J. Stege, A.W.T. Konings, J. Landry, Cells Overexpressing Hsp27 Show Accelerated Recovery from Heat-Induced Nuclear-Protein Aggregation Biochemical and Biophysical Research Communications. ,vol. 204, pp. 1170- 1177 ,(1994) , 10.1006/BBRC.1994.2586