Increased risk of second cancers following breast cancer: role of the initial treatment.

摘要: Objectives and methods.The risk of second primary malignancies (SMN) was studied in a cohort 4,416 one-year survivors breast cancer. The role the menopausal status initial treatment modalities (surgery, radiotherapy, chemotherapy) investigated. Results.Excluding cancer non-melanoma skin cancer, total 193 (4.4%) patients developed SMN between 1973 1992, compared with 136 expected (Standardised Incidence Ratio, SIR = 1.4, 95% CI (1.2–1.6)). No trend towards either an increase or decrease noted SIR time after (p = 0.2). greatest relative concerned soft tissue cancers (SIR = 13.0, CI: 6.8–22.3), followed by leukaemia (SIR = 3.1, 1.7–5.0), melanoma (SIR  =  2.7, 1.4–4.8), kidney (SIR = 2.5, 1.2–4.5), ovary (SIR = 2.0, 1.2–3.1) uterine tumours (SIR = 1.9, 1.4–2.5). 3.0 (95% 1.8–4.7) women under 40 at 1.9 : 1.4 – 2.4) those aged 40–49 1.2 1.0–1.4) 50 more. In 2,514 who had received radiotherapy as without chemotherapy, for all 1.6 1.1–2.3) fold higher than not treatment. Conclusion.In conclusion, this study confirms increased treated particularly were younger Our results also suggest that may play onset these lesions.