Specific binding of 1,25 dihydroxyvitamin D3 in the VX2 carcinoma
作者： H.C. Freake , E. Spanos , J.A. Eisman , C.S.B. Galasko , T.J. Martin
DOI: 10.1016/S0006-291X(80)80036-2
关键词: Internal medicine 、 Tumour invasion 、 Receptor 、 Carcinoma 、 Human breast 、 Endocrinology 、 Biology 、 Prostaglandin E 、 Molecular biology 、 Vx2 carcinoma 、 Biophysics 、 Cell biology 、 Biochemistry
摘要: Summary The VX 2 carcinoma is a transplantable rabbit which has been extensively studied as model of tumour invasion bone. produces large amounts prostaglandin E but also resorbs bone directly. In this report we show that the contains specific, high affinity (Kd 2.0 × 10 −11 M) receptor for 1,25 dihydroxy D 3 sediments at 3.5S in sucrose density gradients. Its characteristics are very similar to those 1,25(OH) human breast carcinoma.
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