Mitochondrial oxidative stress mediates high-phosphate-induced secretory defects and apoptosis in insulin-secreting cells.
作者： Tuyet Thi Nguyen , Xianglan Quan , Kyu-Hee Hwang , Shanhua Xu , Ranjan Das
DOI: 10.1152/AJPENDO.00009.2015
关键词: Unfolded protein response 、 Mitochondrial permeability transition pore 、 Superoxide 、 Endocrinology 、 Biochemistry 、 Cell biology 、 Internal medicine 、 Apoptosis 、 Biology 、 Mitochondrion 、 Pi 、 Oxidative stress 、 Insulin
摘要: Inorganic phosphate (Pi) plays an important role in cell signaling and energy metabolism. In insulin-releasing cells, Pi transport into mitochondria is essential for the generation of ATP, a signal...
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