Review article: CYTOCHROME P450 ENZYME MEDIATED HERBAL DRUG INTERACTIONS (PART 2)

摘要: To date, a number of significant herbal drug interactions have their origins in the alteration cytochrome P450 (CYP) activity by various phytochemicals. Among most noteworthy are those involving St. John's wort and drugs metabolized human CYP3A4 enzyme. This review article is continued work from our previous (Part 1) published this journal (Wanwimolruk Prachayasittikul, 2014). extends scope to six more herbs updates information on interactions. These include black cohosh, ginseng, grape seed extract, green tea, kava, saw palmetto some important Chinese medicines also presented. Even though there been many studies determine effects CYP, them were vitro animal studies. Therefore, limited predicting clinical relevance It appeared that majority no clear CYPs examined. For example, existing trial data imply ginseng unlikely affect pharmacokinetics conventional CYPs. extract adverse when they concomitantly taken with prescription CYP substrates. Although few potential CYP-mediated produced present suggest kava supplements ability inhibit CYP1A2 CYP2E1 significantly. caution should be patients take or substrate as it may enhance therapeutic effects. Despite long use traditional medicines, little known about these herbs. Many popularly used shown significantly change CYP. However, confirming evidence studies, precaution exercised taking Currently sufficient indicate can occur lead serious consequence. Further research conducted verify Education communication products important.