Herbal Supplement-Based Interactions

摘要: As herbal supplements are purchased and used by more than 25% of the general population, supplement-based interactions have become increasingly reported. The primary mechanism herb–drug is modulation metabolizing enzymes and/or transporters. This chapter highlights effects several top selling (St. John’s wort, garlic, ginseng, milk thistle, ginkgo, others) important constituents (flavonoids isothiocyanates) on enzymes/transporters subsequent interactions. Literature reports indicate that these supplements/constituents modulate various phase I/II transporters at both functional expression levels an impact pharmacokinetics co-administered drugs, which mainly metabolized/transported enzymes/transporters. alteration in enzyme/transporter function product may vary markedly due to different manufacturers or lots products, doses, drug substrates, experimental systems evaluate potential Many been investigated only vitro. Further vivo animal studies clinical trials need be carried out confirm vitro observations determine relevance herbal–drug