Isolation and chromosomal assignment of 100 highly informative human simple sequence repeat polymorphisms
作者： Thomas J. Hudson , Marcy Engelstein , Matthias K. Lee , Elizabeth C. Ho , Marc J. Rubenfield
DOI: 10.1016/0888-7543(92)90133-D
关键词: Genetic marker 、 Molecular biology 、 Chromosome 15 、 Gene mapping 、 Restriction fragment length polymorphism 、 Genetics 、 DNA 、 Chromosome 、 Biology 、 Repeated sequence 、 Somatic cell
摘要: One hundred highly informative simple sequence repeat (SSR) polymorphisms have been isolated and mapped to specific human chromosomes by somatic cell hybrid analysis. These markers include 97 (CA)n, 2 (AGAT)n, a single (AACT)n repeat. All the SSRs heterozygosities greater than 0.50 can be amplified using identical PCR conditions. At least one SSR was detected on every chromosome, except for 22 Y. The frequency of (CA)n repeats each chromosome proportional relative chromosomal length, 15, which substantial excess identified.
sci-hub.se 参考文章(24)
J L Weber, P E May, Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction American Journal of Human Genetics. ,vol. 44, pp. 388- 396 ,(1989)
D Botstein, R W Davis, R L White, M Skolnick, Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics. ,vol. 32, pp. 314- 331 ,(1980)
R.L. Stallings, A.F. Ford, D. Nelson, D.C. Torney, C.E. Hildebrand, R.K. Moyzis, Evolution and distribution of (GT)n repetitive sequences in mammalian genomes Genomics. ,vol. 10, pp. 807- 815 ,(1991) , 10.1016/0888-7543(91)90467-S
H. Hamada, M. G. Petrino, T. Kakunaga, A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 79, pp. 6465- 6469 ,(1982) , 10.1073/PNAS.79.21.6465
R DECKER, J MOORE, B PONDER, J WEBER, Linkage mapping of human chromosome 10 microsatellite polymorphisms. Genomics. ,vol. 12, pp. 604- 606 ,(1992) , 10.1016/0888-7543(92)90455-2
T. Mohandas, C. Heinzmann, R. S. Sparkes, J. Wasmuth, P. Edwards, A. J. Lusis, Assignment of human 3-hydroxy-3-methylglutaryl coenzyme A reductase gene to q13----q23 region of chromosome 5. Somatic Cell and Molecular Genetics. ,vol. 12, pp. 89- 94 ,(1986) , 10.1007/BF01560731
James L. Weber, Informativeness of human (dC-dA)n.(dG-dT)n polymorphisms. Genomics. ,vol. 7, pp. 524- 530 ,(1990) , 10.1016/0888-7543(90)90195-Z
G. Church, S Kieffer-Higgins, Multiplex DNA Sequencing Science. ,vol. 240, pp. 185- 188 ,(1988) , 10.1126/SCIENCE.3353714
N ROYLE, Clustering of hypervariable minisatellites in the proterminal regions of human autosomes Genomics. ,vol. 3, pp. 352- 360 ,(1988) , 10.1016/0888-7543(88)90127-9
Hiroshi Hamada, Takeo Kakunaga, Potential Z-DNA forming sequences are highly dispersed in the human genome Nature. ,vol. 298, pp. 396- 398 ,(1982) , 10.1038/298396A0