Facile synthesis of amide and amine derivatives of 2,2,3,3-tetramethylcyclopropanecarboxylic acid
作者： Hui-Long Wang , Wen-Feng Jiang , Zhe-Qi Li
DOI: 10.3184/030823409X12474221035208
关键词: Reagent 、 Thionyl chloride 、 Chemistry 、 Amine derivatives 、 Organic chemistry 、 Redox 、 Stoichiometry 、 Amide
摘要: An efficient one-pot procedure for the synthesis of amide derivatives 2,2,3,3-tetramethylpropanecarboxylic acid (TMCA) that involves treating TMCA in N,N-dimethylacetamide (DMAC) with thionyl chloride and stoichiometric amounts reactant amines has been developed. The combined reagent TiCl 4 /NaBH was found to be effective reduction corresponding amines.
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