Spatial Microstimuli in Endothelial Mechanosignaling

摘要: Descriptive and quantitative analyses of microstimuli in living endothelial cells strongly support an integrated mechanism mechanotransduction regulated by the spatial organization multiple structural signaling networks. Endothelial responses to blood flow are at levels extending over scales from vascular beds single cells, subcellular structures, individual molecules. Microstimuli cellular exhibit temporal complexities that increasingly accessible measurement. We address cell physical interface between flow-related forces biomechanical cell. Live imaging computational dynamics, two important approaches microstimulation this scale, briefly reviewed.