The role of telomerase activity in hepatocellular carcinoma.
作者： Ken Shirabe , Yoshihiko Maehara , Kenji Takenaka , Hirofumi Hasegawa , Tomonobu Gion
DOI: 10.1016/S0002-9270(99)00914-4
关键词: Telomerase 、 Cancer research 、 Carcinoma 、 Biopsy 、 Hepatectomy 、 Medicine 、 Pathology 、 Prothrombin level 、 Survival rate 、 Hepatocellular carcinoma 、 Stage (cooking)
摘要: Abstract OBJECTIVE: The aim of this study was to clarify the role telomerase activity in hepatocellular carcinoma (HCC). METHODS: Specimens from both HCC and noncancerous liver were obtained 39 patients with using a 14-gauge biopsy needle immediately after laparotomy. Telomerase determined telomeric repeat amplification protocol assay. 3+ defined as high group, 2+ or less low group. In liver, more an increased 1+ nonincreased correlation between clinicopathological factors, including prognosis, investigated. RESULTS: activities HCCs 0 one patient, two, seven, 29 patients. disease-free survival rate group significantly worse than that des-γ-carboxy prothrombin level (median, 330 mAU/ml) higher 150 mAU/ml). A multivariate analysis revealed TNM stage, HCC, female gender, α-fetoprotein value independent significant factors related be early recurrence. incidence multicentric occurrence (53.3%) tended (27.3%). CONCLUSION: correlated potential malignant, which expressed earlier recurrence hepatectomy activity.
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Richard Peto, M. C. Pike, Conservatism of the approximation sigma (O-E)2-E in the logrank test for survival data or tumor incidence data. Biometrics. ,vol. 29, pp. 579- 584 ,(1973) , 10.2307/2529177
CM Counter, J Gupta, CB Harley, B Leber, S Bacchetti, Telomerase activity in normal leukocytes and in hematologic malignancies. Blood. ,vol. 85, pp. 2315- 2320 ,(1995) , 10.1182/BLOOD.V85.9.2315.BLOODJOURNAL8592315
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Goro Kajiyama, Hidetoshi Tahara, Toshinori Ide, Ryo Nakashio, Eiichi Tahara, Mikiya Kitamoto, Jerry W. Shay, Toshio Nakanishi, Telomerase Activity in Human Liver Tissues: Comparison between Chronic Liver Disease and Hepatocellular Carcinomas Cancer Research. ,vol. 55, pp. 2734- 2736 ,(1995)
T de Lange, L Shiue, R M Myers, D R Cox, S L Naylor, A M Killery, H E Varmus, Structure and variability of human chromosome ends. Molecular and Cellular Biology. ,vol. 10, pp. 518- 527 ,(1990) , 10.1128/MCB.10.2.518
Mieczyslaw A. Piatyszek, Naokuni Tatsumoto, Takashi Kodama, Eiso Hiyama, Takashi Yokoyama, Yoshiaki Murakami, Jerry W. Shay, Yuji Imamura, Yuichiro Matsuura, Keiko Hiyama, Telomerase activity in gastric cancer. Cancer Research. ,vol. 55, pp. 3258- 3262 ,(1995)
Silvia Bacchetti, Hal W. Hirte, Kazy Hay, Steven Gallinger, Corinne Chadeneau, Telomerase activity associated with acquisition of malignancy in human colorectal cancer. Cancer Research. ,vol. 55, pp. 2533- 2536 ,(1995)
Hugh A. Edmondson, Paul E. Steiner, Primary carcinoma of the liver.A study of 100 cases among 48,900 necropsies Cancer. ,vol. 7, pp. 462- 503 ,(1954) , 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E
Yoshiaki Urabe, Kazuhiro Nouso, Toshihiro Higashi, Harushige Nakatsukasa, Naoki Hino, Kouzou Ashida, Nobuyuki Kinugasa, Keigo Yoshida, Shuji Uematsu, Takao Tsuji, Telomere length in human liver diseases Liver. ,vol. 16, pp. 293- 297 ,(2008) , 10.1111/J.1600-0676.1996.TB00748.X
Hey-Chi Hsu, Tzyy-Jen Chiou, Jen-Yang Chen, Chu-Shue Lee, Po-Huang Lee, Shian-Yang Peng, Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules Hepatology. ,vol. 13, pp. 923- 928 ,(1991) , 10.1002/HEP.1840130520