Effect of pentobarbital on normal brain protection and on the response of 9L rat brain tumor to radiation therapy.

摘要: ✓ The authors attempted to confirm published reports that pentobarbital protects against radiation-induced damage normal rat brain, as well enhances radiotherapeutic efficacy in a brain tumor model. They evaluated animal survival 9L gliosarcoma-burdened rats received whole-brain radiation therapy (16, 24, 32, or 40 Gy) while under intraperitoneal (60 mg/kg) intramuscular ketamine sedation. animals were examined at autopsy attribute death either intracranial growth toxicity the absence of discernible tumor. There was no difference between two anesthesia groups regarding unirradiated animals. Radiation produced significant dose-dependent prolongation survival, which limited by development tissue higher doses. When compared anesthesia, appeared offer some protection (not statistically significant) early (but ...