AMP-Activated Protein Kinase and Host Defense against Infection

摘要: 5′-AMP-activated protein kinase (AMPK) plays diverse roles in various physiological and pathological conditions. AMPK is involved energy metabolism, which perturbed by infectious stimuli. Indeed, pathogens modulate activity, affects host defenses against infection. In some viral infections, including hepatitis B C activation beneficial, but others such as dengue virus, Ebola human cytomegaloviral a detrimental role. AMPK-targeting agents or small molecules enhance the antiviral response contribute to control of microbial parasitic infections. addition, this review focuses on double-edged role innate adaptive immune responses Understanding how regulates will enable development more effective host-directed therapeutic strategies diseases.