作者: Patrick Lajoie , Ivan R. Nabi
DOI: 10.1016/S1937-6448(10)82003-9
关键词: Receptor-mediated endocytosis 、 Endocytosis 、 Lipid raft 、 Sphingolipid 、 Caveolin 、 Biology 、 Caveolae 、 Cell biology 、 Actin cytoskeleton 、 Dynamin
摘要: Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids that involved the lateral compartmentalization of molecules at cell surface. Internalization ligands receptors by these domains occurs via a process defined as raft-dependent endocytosis. Caveolae caveolin-1-enriched smooth invaginations form subdomain lipid rafts. Endocytosis rafts, including caveolar but also noncaveolar dynamin-dependent dynamin-independent pathways, is characterized its sensitivity clathrin-independence. In this review we will characterize caveolae, their endocytosis regulation actin cytoskeleton, caveolin-1, dynamin, cholesterol.