Lipid rafts, caveolae, and their endocytosis.

作者: Patrick Lajoie , Ivan R. Nabi

DOI: 10.1016/S1937-6448(10)82003-9

关键词: Receptor-mediated endocytosisEndocytosisLipid raftSphingolipidCaveolinBiologyCaveolaeCell biologyActin cytoskeletonDynamin

摘要: Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids that involved the lateral compartmentalization of molecules at cell surface. Internalization ligands receptors by these domains occurs via a process defined as raft-dependent endocytosis. Caveolae caveolin-1-enriched smooth invaginations form subdomain lipid rafts. Endocytosis rafts, including caveolar but also noncaveolar dynamin-dependent dynamin-independent pathways, is characterized its sensitivity clathrin-independence. In this review we will characterize caveolae, their endocytosis regulation actin cytoskeleton, caveolin-1, dynamin, cholesterol.

参考文章(198)
Amnon Schlegel, Richard G Pestell, Michael P Lisanti, Caveolins in cholesterol trafficking and signal transduction: implications for human disease Frontiers in Bioscience. ,vol. 5, pp. d929- ,(2000) , 10.2741/SCHLEGEL
Richard D. Minshall, Chinnaswamy Tiruppathi, Stephen M. Vogel, Walter D. Niles, Annette Gilchrist, Heidi E. Hamm, Asrar B. Malik, Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway Journal of Cell Biology. ,vol. 150, pp. 1057- 1070 ,(2000) , 10.1083/JCB.150.5.1057
Ayesha N. Shajahan, Barbara K. Timblin, Raudel Sandoval, Chinnaswamy Tiruppathi, Asrar B. Malik, Richard D. Minshall, Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. Journal of Biological Chemistry. ,vol. 279, pp. 20392- 20400 ,(2004) , 10.1074/JBC.M308710200
Ivan R. Nabi, Phuong U. Le, Caveolae/raft-dependent endocytosis. Journal of Cell Biology. ,vol. 161, pp. 673- 677 ,(2003) , 10.1083/JCB.200302028
J. Schnitzer, D. McIntosh, A. Dvorak, J. Liu, P. Oh, Separation of caveolae from associated microdomains of GPI-anchored proteins Science. ,vol. 269, pp. 1435- 1439 ,(1995) , 10.1126/SCIENCE.7660128
David A Zacharias, Jonathan D Violin, Alexandra C Newton, Roger Y Tsien, Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells Science. ,vol. 296, pp. 913- 916 ,(2002) , 10.1126/SCIENCE.1068539
Antonella Viola, Antonio Lanzavecchia, T-cell activation and the dynamic world of rafts Apmis. ,vol. 107, pp. 615- 623 ,(1999) , 10.1111/J.1699-0463.1999.TB01450.X
Arnold Hayer, Miriam Stoeber, Christin Bissig, Ari Helenius, Biogenesis of caveolae: stepwise assembly of large caveolin and cavin complexes. Traffic. ,vol. 11, pp. 361- 382 ,(2010) , 10.1111/J.1600-0854.2009.01023.X
Kai Simons, Jean Gruenberg, Jamming the endosomal system: lipid rafts and lysosomal storage diseases. Trends in Cell Biology. ,vol. 10, pp. 459- 462 ,(2000) , 10.1016/S0962-8924(00)01847-X
G. Sowa, M. Pypaert, D. Fulton, W. C. Sessa, The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 6511- 6516 ,(2003) , 10.1073/PNAS.1031672100