Gene Transfer into Primates and Prospects for Gene Therapy in Humans
作者： Kenneth Cornetta , Robert Wieder , W. French Anderson
DOI: 10.1016/S0079-6603(08)60179-8
关键词: Vector (molecular biology) 、 Gene transfer 、 Adenosine deaminase 、 Genetics 、 Gene 、 Genetic enhancement 、 Bone marrow 、 Biology 、 In vitro 、 Cell biology 、 In vivo
摘要: Publisher Summary The ability to transfer and express genetic material in mammalian cells presents a new approach the treatment of many diseases. Retroviral-mediated gene has proven be an efficient system vitro. While vivo expression been obtained mouse, vectors expressing murine systems do not necessarily primates. Retroviral infect primate bone marrow transferred genes . SAX vector appears human adenosine deaminase (ADA) at normal levels, but infection efficiency is low (
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