Reprogramming: A New Era in Regenerative Medicine
作者： Vivi M. Heine , Stephanie Dooves , Dwayne Holmes , Judith Wagner
DOI: 10.1007/978-94-007-2816-5_1
关键词: Somatic cell 、 Somatic cell nuclear transfer 、 Induced pluripotent stem cell 、 Embryonic stem cell 、 Regenerative medicine 、 Reprogramming 、 Transcription factor 、 Neural stem cell 、 Biology 、 Cell biology
摘要: Embryonic stem cells (ESCs) exhibit the capacity for unlimited self-renewal and an ability to generate all somatic cell lines. However, political, ethical practical obstacles, such as rejection of ESC-derived tissue by patients, obstruct potential using human ESCs (hESCs) in regenerative medicine. Still, extreme plasticity proliferative nature make them ‘gold standard’ match or beat. While some reprogramming technologies, nuclear transfer (SCNT) , are capable generating ESC-like states they face similar challenges associated with ESCs. In 2006, Takahashi Yamanaka reported development so-called “induced pluripotent cells” (iPSCs) from adult mouse fibroblasts. These were produced inducing expression four transcription factors (TFs). last few years, many alternative strategies have been studied order develop a safe efficient method therapeutic applications.
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