Stage-dependent Olig2 expression in motor neurons and oligodendrocytes differentiated from embryonic stem cells.
作者： Soojung Shin , Haipeng Xue , Mark P Mattson , Mahendra S Rao , None
关键词:
摘要: Although embryonic stem (ES) cells are capable of forming any cell type in the body, mechanisms that control type-specific differentiation largely unknown. In present study, we examined process to motor neurons and oligodendrocytes from mouse (Olig2GFP) ES cells. Mouse undergo a sequential over 3-week period generate oligodendrocytes. At day 7 differentiation, Olig2-expressing biased neuronal lineage. However, further (day 32) resulted majority exhibiting an oligodendrocyte phenotype as well reduced ability make neurons. Exposure human Sonic hedgehog (Shh) likewise enhanced neuron differentiation. Our results establish requirements for directing become show cell-derived Olig2 + can give rise both oligodendro...
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Muddanna S. Rao, Ashok K. Shetty, Efficacy of doublecortin as a marker to analyse the absolute number and dendritic growth of newly generated neurons in the adult dentate gyrus. European Journal of Neuroscience. ,vol. 19, pp. 234- 246 ,(2004) , 10.1111/J.0953-816X.2003.03123.X
Kiichi Watanabe, Daisuke Kamiya, Ayaka Nishiyama, Tomoko Katayama, Satoshi Nozaki, Hiroshi Kawasaki, Yasuyoshi Watanabe, Kenji Mizuseki, Yoshiki Sasai, Directed differentiation of telencephalic precursors from embryonic stem cells Nature Neuroscience. ,vol. 8, pp. 288- 296 ,(2005) , 10.1038/NN1402
Rumiko Mizuguchi, Michiya Sugimori, Hirohide Takebayashi, Hidetaka Kosako, Motoshi Nagao, Shosei Yoshida, Yo-ichi Nabeshima, Kenji Shimamura, Masato Nakafuku, Combinatorial Roles of Olig2 and Neurogenin2 in the Coordinated Induction of Pan-Neuronal and Subtype-Specific Properties of Motoneurons Neuron. ,vol. 31, pp. 757- 771 ,(2001) , 10.1016/S0896-6273(01)00413-5
Solen Gokhan, Mireya Marin-Husstege, Shau Yu Yung, Darah Fontanez, Patrizia Casaccia-Bonnefil, Mark F Mehler, Combinatorial Profiles of Oligodendrocyte-Selective Classes of Transcriptional Regulators Differentially Modulate Myelin Basic Protein Gene Expression The Journal of Neuroscience. ,vol. 25, pp. 8311- 8321 ,(2005) , 10.1523/JNEUROSCI.1850-05.2005
Urban Lendahl, Lyle B. Zimmerman, Ronald D.G. McKay, CNS stem cells express a new class of intermediate filament protein. Cell. ,vol. 60, pp. 585- 595 ,(1990) , 10.1016/0092-8674(90)90662-X
Ying Liu, Mahendra Rao, Oligodendrocytes, GRPs and MNOPs. Trends in Neurosciences. ,vol. 26, pp. 410- 412 ,(2003) , 10.1016/S0166-2236(03)00201-7
Jeffrey Lee, Yuanyuan Wu, Yingchuan Qi, Haipeng Xue, Ying Liu, David Scheel, Michael German, Mengsheng Qiu, Francois Guillemot, Mahendra Rao, Neurogenin3 Participates in Gliogenesis in the Developing Vertebrate Spinal Cord Developmental Biology. ,vol. 253, pp. 84- 98 ,(2003) , 10.1006/DBIO.2002.0868
Miriam Bibel, Jens Richter, Katrin Schrenk, Kerry Lee Tucker, Volker Staiger, Martin Korte, Magdalena Goetz, Yves-Alain Barde, Differentiation of mouse embryonic stem cells into a defined neuronal lineage Nature Neuroscience. ,vol. 7, pp. 1003- 1009 ,(2004) , 10.1038/NN1301
Soojung Shin, Maisam Mitalipova, Scott Noggle, Deanne Tibbitts, Alison Venable, Raj Rao, Steven L. Stice, Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions. Stem Cells. ,vol. 24, pp. 125- 138 ,(2006) , 10.1634/STEMCELLS.2004-0150
Victoria Graham, Jane Khudyakov, Pamela Ellis, Larysa Pevny, SOX2 Functions to Maintain Neural Progenitor Identity Neuron. ,vol. 39, pp. 749- 765 ,(2003) , 10.1016/S0896-6273(03)00497-5