Combinatorial Profiles of Oligodendrocyte-Selective Classes of Transcriptional Regulators Differentially Modulate Myelin Basic Protein Gene Expression
作者： Solen Gokhan , Mireya Marin-Husstege , Shau Yu Yung , Darah Fontanez , Patrizia Casaccia-Bonnefil
DOI: 10.1523/JNEUROSCI.1850-05.2005
关键词: Transcription factor 、 Genetics 、 Gene expression 、 Myelin basic protein 、 Oligodendrocyte 、 Transcriptional regulation 、 SOX10 、 Myelin 、 Cell biology 、 OLIG2 、 Biology
摘要: Recent studies suggest that specific neural basic helix-loop-helix (HLH; i.e., Olig1 and Olig2, Mash1), associated inhibitory HLH (i.e., Id2 Id4), high-mobility group domain Sox10), homeodomain Nkx2.2) transcription factors are involved in oligodendrocyte (OL) lineage specification progressive stages of maturation including myelination. However, the developmental interplay among these lineage-selective determinants, a cell- maturational stage-specific context, has not yet been defined. We show here vivo vitro expression profiles for distinct classes transcriptional regulators OLs. OL characterized by dynamic changes subcellular distribution different permutations combinatorial codes. Transient transfections precise codes with luciferase reporter gene driven myelin protein promoter define how molecular composition complexes modulate expression. Our overall findings between activators orchestrate during terminal mammalian CNS.
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sci-hub.se 参考文章(47)
Mireya Marin-Husstege, Michela Muggironi, Aixiao Liu, Patricia Casaccia-Bonnefil, Histone Deacetylase Activity Is Necessary for Oligodendrocyte Lineage Progression The Journal of Neuroscience. ,vol. 22, pp. 10333- 10345 ,(2002) , 10.1523/JNEUROSCI.22-23-10333.2002
Toru Kondo, Martin Raff, Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells Science. ,vol. 289, pp. 1754- 1757 ,(2000) , 10.1126/SCIENCE.289.5485.1754
Béatrice Durand, Martin Raff, A cell-intrinsic timer that operates during oligodendrocyte development BioEssays. ,vol. 22, pp. 64- 71 ,(2000) , 10.1002/(SICI)1521-1878(200001)22:1<64::AID-BIES11>3.0.CO;2-Q
Gino Poulin, Mélanie Lebel, Michel Chamberland, Francois W Paradis, Jacques Drouin, None, Specific Protein-Protein Interaction between Basic Helix-Loop-Helix Transcription Factors and Homeoproteins of the Pitx Family Molecular and Cellular Biology. ,vol. 20, pp. 4826- 4837 ,(2000) , 10.1128/MCB.20.13.4826-4837.2000
Siming Shen, Jiadong Li, Patrizia Casaccia-Bonnefil, Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain Journal of Cell Biology. ,vol. 169, pp. 577- 589 ,(2005) , 10.1083/JCB.200412101
Qiao Zhou, David J. Anderson, The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification Cell. ,vol. 109, pp. 61- 73 ,(2002) , 10.1016/S0092-8674(02)00677-3
Q.Richard Lu, Tao Sun, Zhimin Zhu, Nan Ma, Meritxell Garcia, Charles D. Stiles, David H. Rowitch, Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection Cell. ,vol. 109, pp. 75- 86 ,(2002) , 10.1016/S0092-8674(02)00678-5
Aixiao Liu, Christine Stadelmann, Mario Moscarello, Wolfgang Bruck, Fabrizio G Mastronardi, Patrizia Casaccia-Bonnefil, Expression of Stathmin, a Developmentally Controlled Cytoskeleton-Regulating Molecule, in Demyelinating Disorders The Journal of Neuroscience. ,vol. 25, pp. 737- 747 ,(2005) , 10.1523/JNEUROSCI.4174-04.2005
Tao Sun, Hualing Dong, Lizi Wu, Michael Kane, David H. Rowitch, Charles D. Stiles, Cross-Repressive Interaction of the Olig2 and Nkx2.2 Transcription Factors in Developing Neural Tube Associated with Formation of a Specific Physical Complex The Journal of Neuroscience. ,vol. 23, pp. 9547- 9556 ,(2003) , 10.1523/JNEUROSCI.23-29-09547.2003
Nicholas Gaiano, Gord Fishell, Jeffrey S. Nye, Christopher B. Chambers, Hoang Nguyen, Ying Peng, Spatiotemporal selectivity of response to Notch1 signals in mammalian forebrain precursors Development. ,vol. 128, pp. 689- 702 ,(2001) , 10.1242/DEV.128.5.689