Requirement for reverse immune surveillance for the growth of germinal center-derived murine lymphomas.

摘要: The concept of reverse immune surveillance, first conceived over 12 years ago, described the relationship that existed between germinal center-derived B cell lymphoma cells and host system in SjL/J mice. According to recognition tumor antigens a response by is required for growth. phenomenon surveillance related lymphomas has recently also been characterized another inbred mouse strain, C57L/J. Moreover, elements have observed several other strains develop lymphomas, suggesting this lymphomagenic mechanism may be more common than envisioned. In SJL C57L mice, express an MMTV-encoded superantigen (vSAg29) stimulates syngeneic CD4+ T bearing Vbeta16 their TCR. contrast mRNAs MMTVs normal cells, vSAg29 mRNA initiates env (META) region, undergoes splicing 3' continues through LTR. Copious cytokine production, including IFN-gamma, IL-4 IL-5 accompanies vSAg. addition cytokines produced vSAg-responsive recent evidence indicates cytokine, LTalphabeta2, which expressed on surface, plays role promotion It possible interaction with LTbeta-R follicular dendritic or stromal facilitates growth preventing apoptosis malignant cells. To what degree these findings are relevant development and/or human remains determined. However, endogenous retroviral sequences do exist genome. Interestingly, some homologous MMTV, transcribed lymphoblastoid Moreover microorganisms infectious such as EBV Herpes Virus 8, produce superantigens.