Immunomodulation with soluble IFN-gamma receptor: preliminary study.
作者： Laurence Ozmen , Michael Fountoulakis , Reiner Gentz , Gianni Garotta
DOI: 10.1016/B978-0-12-364935-5.50014-6
关键词: Antigenicity 、 Biological activity 、 Peptide sequence 、 Antagonist 、 Cell surface receptor 、 In vivo 、 Receptor 、 Biology 、 Interferon gamma 、 Molecular biology
摘要: Several in vivo experiments support the hypothesis that an IFN-gamma antagonist may have therapeutic applications autoimmune diseases, hypersensitivities, and alloreactions. exerts its biological activity through binding to a single-chain cell surface receptor. The protein corresponds external domain of mouse receptor was expressed insect cells infected with recombinant baculovirus; this characterized used as prototype antagonist. This does not show any strong antigenicity after injection mice. Despite blood half-life only 1-3 hr demonstrated pharmacokinetic experiments, soluble R able modify onset acute GVHD (alloreaction) chronic (lupuslike disease).
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