The mouse immune interferon receptor gene is located on chromosome 10.

摘要: Abstract When mouse L cells are incubated with 32P-labeled recombinant murine immune interferon ( [32P]Mu-IFN-gamma) and subsequently cross-linked disuccinimidyl suberate, a major complex an apparent molecular mass of 95,000-125,000 daltons can be visualized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The was not formed when the binding performed in presence excess unlabeled Mu-IFN-gamma or Chinese hamster ovary were used. This therefore represents receptor (or its interferon-binding subunit). chromosomal location subunit receptor) gene, termed Ifgr, identified performing cross-linking reactions on series mouse-hamster somatic cell hybrids different subsets chromosomes. chromosome 10 shown to necessary sufficient for formation complex. Thus, gene coding localized 10. this hybrid sufficient, however, confer antiviral resistance they treated challenged encephalomyocarditis virus.