Sublocalization of the human interferon-gamma receptor accessory factor gene and characterization of accessory factor activity by yeast artificial chromosomal fragmentation.
作者： J.R. Cook , S.L. Emanuel , R.J. Donnelly , J. Soh , T.M. Mariano
DOI: 10.1016/S0021-9258(17)37475-6
关键词: Chinese hamster ovary cell 、 Genetics 、 Phosphoribosylglycinamide formyltransferase 、 Gene 、 Molecular biology 、 Biology 、 Chromosome 、 Major histocompatibility complex 、 Yeast artificial chromosome 、 Transcription factor 、 Interferon
摘要: A chromosomal fragmentation procedure was employed to produce a deletion set of yeast artificial chromosomes (YACs) from parental YAC, GART D142H8, known map human chromosome 21q and encode the interferon-gamma receptor (Hu-IFN-gamma R) accessory factor gene as well phosphoribosylglycinamide formyltransferase (GART) gene. When expressed in Chinese hamster ovary cells, these deleted YACs retain activity, judged by major histocompatibility complex class I antigen inducibility, until deletions acentric end exceed 390 kilobases (kb). Therefore, (AF-1) can be localized 150-kb region at left (centric) 540-kb YAC. Cells containing functional are also able induce ISGF3 gamma gamma-activated (GAF) transcription factors, but were not protected against encephalomyocarditis virus (EMCV) upon treatment with Hu-IFN-gamma. Hu-IFN-gamma R AF-1 sufficient for some, all, actions We postulate that an additional (AF-2) required antiviral activity EMCV is encoded on 21q.
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