Biologic functions of the IFN-γ receptors
作者： G. Tau , P. Rothman
DOI: 10.1034/J.1398-9995.1999.00099.X
关键词:
摘要: Interferon-gamma (IFN-gamma) is a cytokine that plays an important role in inducing and modulating array of immune responses. Cellular responses to IFN-gamma are mediated by its heterodimeric cell-surface receptor (IFN-gammaR), which activates downstream signal transduction cascades, ultimately leading the regulation gene expression. In order study number pathways, researchers have generated mice with altered patterns IFN-gammaR These studies, together analyses naturally occurring mutations man, been instrumental elucidating diverse functions IFN-gamma, subject this review.
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