Recovery from viral encephalomyelitis: immune-mediated noncytolytic virus clearance from neurons.
作者： Diane E. Griffin
DOI: 10.1007/S12026-009-8143-4
关键词: Immune system 、 Spinal cord 、 Immunology 、 Virus 、 Biology 、 Virology 、 Nervous system 、 Antiviral antibody 、 Antibody 、 Sindbis virus 、 Encephalomyelitis
摘要: Viral encephalomyelitis is caused by virus infections of neurons in the brain and spinal cord. Recovery dependent on immune-mediated control clearance from these terminally differentiated essential cells. Preservation neuronal function for prevention neurologic sequelae such as paralysis, seizures cognitive deficits. Using model system Sindbis virus-induced mice, we have shown that infectious a noncytolytic process. The major effectors are antibody to E2 surface glycoprotein produced B cells, interferon-γ T These work synergy, but populations differ their responses each. Virus least likely be cleared most motor cervical thoracic regions Because infected not eliminated, viral RNA persists long-term needed prevent reactivation. Virus-specific antibody-secreting cells residing nervous after recovery infection important control.
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