Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis.

摘要: Esophagus cancer is the seventh cause of cancer-related deaths globally. In this study, we analyzed interleukin 6 (IL-6) gene expression in human esophagus patients and showed that IL-6 mRNA levels are significantly higher tumor tissues negatively correlated with overall survival, suggesting a potential therapeutic target for cancer. We further demonstrated apigenin, nature flavone product green plants, inhibited transcription Eca-109 Kyse-30 cells. Apigenin dose-dependently cell proliferation promoted apoptosis while stimulating cleaved PARP (poly ADP-ribose polymerase) (C-PARP) caspase-8 expression. It suppressed VEGF (Vascular endothelial growth Factor) tumor-induced angiogenesis. Pretreatment cells could completely reverse apigenin-induced cellular changes. Finally, using preclinical nude mice model subcutaneously xenografted cells, vivo antitumor activity mechanisms apigenin. Taken together, study revealed first time apigenin new inhibitor inhibiting one by which exhibits its anticancer effects. The clinical applications treating warrant investigations.